Sam (Ted Danson), a former pitcher for the Boston Redsox, owns and runs Cheers, a cozy bar in Boston. Somewhat snobby, beautiful and intelligent Diane (Shelley Long) -- forced to become a waitress when her fiance jilts her -- constantly bickers with Sam. Eventually, they fall in love. Several wacky characters make the bar their home-away-from-home, including sarcastic waitress Carla (Rhea Perlman), beer-loving Norm (George Wendt) and Boston letter carrier Cliff (John Ratzenberger).
A few seasons later, Sam sells the bar to buy a boat and sail around the world. But his boat sinks and he returns to bartending. Rebecca (Kirstie Alley), the new (more ambitious) manager, hires him back. They love to hate each other and eventually get together as well.