Make an appointment with the brilliant but socially awkward and neurotic Doc Martin. When Martin develops an aversion to blood, he abandons his career as a celebrated London surgeon and becomes the only doctor in a sleepy small town where his tactless manner soon has the whole town in an uproar.
With Louisa visiting her mother in Spain to get some perspective on their marriage, Martin knows he needs to try to change for the sake of their relationship, so he endeavours to keep his promise to her to see a therapist. Aunt Ruth arranges an appointment for him with Dr Rachel Timoney, but a lifeboat training exercise causes problems for the doctor. Will he get back in time for his first session?
Al welcomes his first fishing guests, but an uninvited one means that a good review is definitely not guaranteed, while Bert decides to try to rejuvenate trade at the restaurant by joining an online voucher scheme. Morwenna asks Martin for a pay rise, and Louisa has to find a new babysitter to look after James Henry and reluctantly decides to offer Janice a trial. Penhale is excited to receive his new police issue Taser, but Portwenn does not exactly offer him plenty of opportunities to try it out.
Martin decides to move out of the Surgery to give Louisa space, leaving Mrs Tishell concerned he will not be able to look after himself on his own. Elsewhere, PC Penhale helps Janice babysit, and Al is very concerned when he finds out about Bert's behaviour and hears there are bailiffs at the restaurant.
Louisa and Martin have their first therapy session together - though neither of them was expecting they would be given homework - while Morwenna is not happy about it when a teenager on work experience starts trying to boss her around in the surgery. Mrs Tishell is surprised when her husband Clive returns and tells her he wants to give things another go, and Louisa has to call Martin when one of her pupils collapses during a school excursion.
After reaching breaking point with being followed around by Buddy, Martin resolves to find a vet to have it put down, while Ruth finds out that Bert has been trying to make his own whisky. Clive is suspicious of Mrs Tishell and who she might be cooking meals for, Penhale makes a hash of asking Janice out, and Louisa and Martin's therapy homework results in a picnic on the beach, where they are interrupted by local vet Angela Sim - who appears to be hallucinating.
Louisa helps out her ex-boyfriend Danny when he brings seven children from London to camp on Ruth's farm - supervised by Al and Bert - while she and Martin plan a date on the advice of Dr Timoney. However, their night at the restaurant is interrupted when Danny calls saying one of the youngsters has gone missing. Things get worse for the couple when Martin uncovers a health scare at James's first birthday party that makes all the guests leave very quickly.
Louisa is not best pleased when her new art teacher Erica wants to try out some rather alternative ideas on the children, while Dr Timoney is involved in a car accident outside the school. Penhale is confused when he is offered a transfer to Exeter, Bert decides to go back to being a handyman, and Louisa and Martin are intrigued when Dr Timoney invites them for an additional therapy session. Plus, an American tourist seeks help from the GP.
Louisa worries Dr Timoney's suggestion that she and Martin aren't meant to be together might have prompted him to leave Portwenn for good. Calling on Ruth, Morwenna and Janice for help, she tries to track the down the missing GP, with no luck. However, what Dr Ellingham's friends and family fail to realise is that he is actually trapped up at the Winton farm, where desperate wife Annie is trying to coerce him into performing a life-saving operation on her terminally ill husband Jim. Meanwhile, Ruth and Bert seek out Al to offer him a proposition regarding the whisky and the B&B.