The multi-generational Reagan family and their dedication to the New York City Police Department. Although being a tight-knit family you may find that the Reagan's have very different ideas of how to gain justice but, they have one thing in common they'll stop at nothing to see justice served because, their occupation is more than just a job it's the family business.
Frank receives an order from the mayor to attend a parade honoring a man who served time for conspiring in an attack against the police. Meanwhile, Danny investigates the return of a teen who suspiciously disappeared 13 years ago; and Jamie and Eddie help a young woman they believe is being exploited by a congressman.
Erin's trial against a notorious human trafficker is jeopardized when the presiding judge is mysteriously found dead. Danny and Baez are put on the case to investigate foul play. Meanwhile, Mayor Dutton opposes Frank's public safety initiative, but City Council Speaker Regina Thomas devises a plan to help Frank bypass the mayor's veto.
Danny and Baez work the case of a detective who was gunned down prior to testifying against a career criminal. Also, Frank personally investigates when Garrett is attacked by a SWAT team outside his home, and Erin brings in a confidential informant against Anthony's wishes
Danny and Baez investigate the murder of a single mother whose ex-husband has a history of violence. Also, Frank deals with the fallout when Mayor Dutton eliminates solitary confinement in prisons and Jamie tries to save a young woman who overdosed.
When a famous basketball player is found dead of an apparent drug overdose, Danny looks into his possible ties to a local drug gang. Also, Erin revisits the case of a man she may have wrongfully convicted years ago, and Frank is approached by Archbishop Kearns (Stacey Keach) regarding an eviction matter Jamie and Eddie are working on.
A case turns personal for Danny when he works to protect a nurse, from her violent ex-boyfriend. Also, Shelly Wayne, an acquaintance of Frank's, comes to him with a theory regarding the death of an inmate and Jamie and Eddie help deliver a baby.
Eddie's judgment is clouded by her past when she arrests a loathed acquaintance from college on questionable charges. Also, Frank is hesitant to mar the spotless record of a member of the force, a decorated U.S. military veteran, who tested for drugs.
As Danny and Baez join a narcotics task force to track down a drug supplier, Baez comes into contact with drugs and is soon fighting for her life from an accidental overdose. Also, Jamie and Eddie work to protect a rehabilitated sex offender.
Erin is conflicted when Jamie and Eddie ask her to help drop old charges against a man, who just bravely rescued a man from a local hostage situation. Also, Danny and Baez work a case involving car thieves and discover the leader is Victor Lugo.
After Anthony is shot while interviewing a witness for an upcoming murder trial, Erin enlists Anthony's archenemy, Danny to find out who was responsible. Also, Jamie and Eddie get in the middle of a standoff and Nicky takes her police exam.
When Henry is the key witness on Danny and Baez's case, his meddling eventually leads then to valuable information; Nicky shocks her family by siding with her activist friend; Jamie and Eddie learn a parole officer is taking advantage of his power.
When a student is shot by a rival gang member in his high school courtyard, Danny and Baez try to get a grasp on the situation to prevent a reoccurrence, but the principal recklessly takes matters into his own hands. Also, Erin tries to help her friend, who is mixed up in an illegal gambling ring. Meanwhile, Governor Mendez tries to frame Frank after one of his top legislative aides is shot by an NYPD officer.