Liz Lemon, played by Saturday Night Live's Tina Fey, is the head writer of the fictional TV show, 'The Girlie Show.' When her old boss dies and a new boss comes in, Liz must try to run a successful TV show without losing her mind.
The "TGS" gang returning from hiatus, only to be shocked by Jack's awful fall programming lineup. Meanwhile, bridezilla Jenna taps Liz to be her maid of honor, and Tracy is invited to a dinner party by Kenneth and Hazel.
Jack and Liz find themselves at odds over political satire at "TGS". Criss and Liz make a surprising relationship breakthrough. Meanwhile, Jenna, discouraged by the disappointing sales of her summer dance hit, is thrilled to learn that Kenneth's mother and her boyfriend still buy music.
Liz and Jack find themselves battling to influence voters in the upcoming presidential election. Meanwhile, as Jenna goes to great lengths to please her new fan base, the writers seek out new ways to mess with her.
Realizing that Jenna could decide the Presidential election, Liz and Jack stage a debate to win her support and her followers. Kenneth turns to Tracy for advice on how to be an informed voter, while Pete tries to recreate the magic of the 2008 election.
Tracy and Jack engage in a battle of wits after Tracy depicts Jack as a villain in his latest project. On Jack's advice, Liz puts her own needs ahead of those of "TGS." Meanwhile, Jenna tries to shield Kenneth from Hazel's manipulation but her own selfishness gets in the way.
After an encounter with Dennis Duffy, Liz and Criss decide to take drastic measures to start a family. As Liz looks toward the future, Jack and Jenna evaluate their own self-worth, and Tracy laments a shocking medical diagnosis.
Jack asks Devin Banks to help him discredit Kaylie Hooper, Jack's teenage nemesis and KableTown's future CEO. Liz considers her options as she tries to become a mother. Tracy directs Octavia Spencer in his movie.
When Jack persuades Liz to go to Florida with him, they make a shocking discovery about his mother. Jenna and Tracy assume responsibility for the show in Liz's absence, resulting in disaster for Kenneth.